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Updated Jun 22, 2026 · Covering v0.107.1 main (Jun 19) · Aeonglass replaces Doormaker, Steam Workshop live, RNG rework (xoshiro256**), Regent 9-card buff, Bestiary · 136K live, 89.2K June avg · All 577 cards & 293 relics rated · 66 in-depth guides + ToC & Related Guides on every page

Beginner

📖 Beginner

Slay the Spire 2 Beginner Guide: From First Run to Consistent Wins

12 min read · Basic rules, map pathing, deck management, combat fundamentals, and common mistakes.
→ 🔄 Transition Guide

STS1 → STS2 Transition Guide: What Every Veteran Needs to Know

14 min read · Key differences, reworked characters, new keywords (Sly/Doom), 7 bad STS1 habits, and a Week 1 plan.
→ 🐳 Starter Guide

Neow's Blessing Tier List: Best Starter Bonuses for Every Character

10 min read · All Neow bonuses ranked S-D, per-character best picks, risk/reward math, which bonuses to avoid.
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Multiplayer

⚔️ Co-op Guide

STS2 Co-op Multiplayer Guide: Mechanics, Synergies & Best Team Comps

15 min read · How 4-player co-op works, shared vs individual systems, best character pairings, team synergy combos, and 10 winning tips.
→ 🤝 Advanced Co-op

Co-op Synergy Deep Dive: Best Team Comps & Role Guide

11 min read · Tank/DPS/Support/Flex roles, Top 5 team comps, synergy matrix, cross-character card combos, tournament lessons.
→ 🤝 Team Comp Tier List

Co-op Team Composition Tier List: Best 2/3/4-Player Combos

13 min read · S-D tier duo/trio/quad rankings, role assignments, card pool conflicts, tournament-proven team comps.
→ 🏆 Co-op Tier List

Co-op Carries Tier List: Best DPS Characters & Comps for Multiplayer

10 min read · S-C tier DPS carry rankings, Devour the Tower data, optimal team compositions by player count.
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Core Mechanics

🃏 Core Guide

Deck Building Principles: How to Build Decks That Win

15 min read · Card evaluation framework, energy curve, archetype synergies, optimal deck size, and anti-trap guide.
→ ⬆️ Advanced

Ascension Guide: All 20 Levels, Modifiers & How to Beat Them

14 min read · Full A1–A20 breakdown, milestone strategies, character recommendations, and 10 universal climbing tips.
→ 🗺️ Strategy

Pathing & Map Strategy: Choose the Right Route Every Run

12 min read · Map reading, node prioritization, act-specific routing, campfire timing, and path flexibility.
→ ❓ Strategy

Event Guide: All ? Room Events, Choices & Optimal Decisions

13 min read · Every event broken down by act, best/worst outcomes, cursed events, and event pathing.
→ 💀 Combat

Elite Enemy Guide: All Elite Fights, Patterns & Rewards

16 min read · Every Elite per act, attack patterns, difficulty rankings, character-specific strategies.
→ 🪙 Economy

Gold & Shop Strategy: When to Buy, What to Prioritize

12 min read · Gold income breakdown, relic buying priorities, card removal math, potion value, act-by-act shopping.
→ 🧪 Beginner

Potion Guide: Tier List, Best Usage, When to Save & Boss Strategies

15 min read · Complete potion tier list (S-D), act-by-act strategy, boss-specific picks, relic synergies, character preferences.
→ ⏱️ Advanced

Speedrun Guide: Fastest Strategies, Character Rankings & Benchmarks

11 min read · Character tier list, Whirlwind rush, time-saving techniques, key bindings, routing, target times.
→ 👹 Boss Guide

Boss Strategy Guide: How to Beat Every Boss (Acts 1-4)

18 min read · All 11 bosses detailed: attack patterns, best cards, preparation checklist, and the Corrupted Heart.
→ 💎 Boss Guide

Aeonglass Boss Strategy: How to Beat the Act 3 Crystal Boss

12 min read · Attack patterns, phase breakdown, best cards & relics, and character-specific tactics for the hardest Act 3 boss.
→ 🦠 Patch Analysis

Infested Prism Rework Guide: v0.106 Enemy Balance Shift

8 min read · New attack patterns, meta impact, and how to adapt your builds to the changed encounter.
→ 📋 Patch Analysis

v0.107.1 Major Update #2 Full Breakdown — Aeonglass, RNG, Regent Buffs

14 min read · Complete strategy analysis: Doormaker removed, Steam Workshop, xoshiro256**, 3 Neow relics, Bestiary.
→ 📊 Meta

Week 26 Meta Report: v0.107.1 First Weekend Data (Jun 22, 2026)

10 min read · Silent 36.3% WR, Necrobinder 34.0%, Regent post-buff surge. 30,416 runs analyzed.
→ 🏆 Build

Top 5 STS2 Builds in the Current Meta — June 2026 (v0.107.1)

12 min read · Sly Discard, Sic 'Em Summon, Block Ramp, Plasma Cycling, Ritual Synergy — full card lists & piloting tips.
→ 💎 Boss Guide

Goodbye Doormaker: Aeonglass Takes Over Act 4 — Full Transition Guide

10 min read · Character matchup rankings, build adjustments, phase-by-phase strategy for the new permanent Act 4 boss.
→ 🛠️ Guide

STS2 Steam Workshop Guide: Install, Best Mods & Create Your Own

11 min read · Top 10 must-have mods, installation walkthrough, mod creation tutorial, and management tips.
→ ⬆️ Advanced

Ascension 20 Challenge Guide: How to Beat the Hardest Difficulty

14 min read · Per-character strategies, key modifiers, deck requirements, and 10 pro tips for consistent A20 clears.
→ 📊 Meta

Week 24 Meta Report: v0.107.0 Patch Impact (June 2–8, 2026)

8 min read · Aeonglass Ebb removal, Juggernaut/Monarch's Gaze buffs, Speedrun Marathon results, win rate shifts for all 5 characters.
→ 🏆 Tournament

Devour the Tower Recap: 34-Streamer Co-op Tournament Analysis

12 min read · Full tournament breakdown: team comps, winning strategies, Necrobinder dominance, and co-op meta lessons.
→ ♾️ Advanced

Infinite Combos: Every Character's Infinite Loop Setup

14 min read · Dropkick loops, discard engines, Recycle combos — all 5 characters' infinite setups.
→ 📊 Meta Report

Week 25 Meta Report: Quiet Window Analysis & v0.108.0 Predictions (Jun 9–15)

10 min read · Player count trends, meta snapshot, community wishlist, and Week 25 timeline analysis.
→ 🔮 Patch Predictions

v0.108.0 Predictions: What Cards Will Be Nerfed & Buffed?

12 min read · Confidence-ranked predictions: Sly Strike/Death Sentence nerf, Defect/Regent buff, Act 4 rumors.
→ ⏱️ Speedrun

Speedrun Optimization Guide: Character Tier List & Turbo Builds

11 min read · Character rankings, Exhaust Engine turbo, settings optimization, pathing & speedrun categories.
→ ✨ New Mechanic

Enchantment System Complete Guide: How Enchanted Cards Work in STS2

12 min read · All enchantment types ranked S-D, best enchanted card combos per character, how to obtain enchantments.
→ 🏛️ New Mechanic

Ancient Boons & Alternate Chapters: Complete System Guide

11 min read · All 8 Ancient Boons ranked, Alternate Chapter routing, boss rewards, per-character best picks.
→ 🗑️ Strategy

Card Removal Strategy: When, What & How Many Cards to Cut

11 min read · Strikes vs Defends removal order, shop removal math, optimal deck sizes, event-based removal.
→ 📈 Advanced

Ascension Guide: All 10 Levels, Modifiers & How to Climb

15 min read · Every A1-A10 modifier, per-character climb strategy, co-op ascension rules, STS1 vs STS2 comparison.
→ ❓ Beginner

Events Guide: All 56 Events, Best Choices & Rewards

20 min read · Every event by act with best choices, risk analysis, and per-character recommendations.
→ 🧪 Tier List

Potions Guide: All 63 Potions Tier List & Best Uses

14 min read · S-Tier to D-Tier rankings, per-character picks, slot management, and upgrade strategies.
→ ⭐ S-Tier

S-Tier Cards: All 10 Ancient-Rarity Cards Analyzed

16 min read · Corruption, Wraith Form, Biased Cognition, Sealed Throne & more — deep build-around strategies.
→ 🔥 Meta

Top 10 Overpowered Cards in STS2 (v0.106.1 Meta)

10 min read · The 10 most broken cards by win-rate data. Sly Gambit, Mass Grave, Calculated Gamble & more ranked.
→ 📝 Patch Analysis

v0.106.0 Patch Analysis: How the Meta Changed (May 2026)

12 min read · Enemy reworks, card buffs/nerfs for all 5 characters, Mummified Hand rework, updated tier lists.
→ 🐉 Patch Analysis

v0.105.0 Patch Analysis: Aeonglass Boss, Bestiary & Defect Renaissance

10 min read · New Act 3 boss replaces Doormaker, Bestiary system, massive Defect buffs, Shatter double-evoke meta.
→ 🔥 Patch Analysis

v0.104.0 Patch Analysis: Ironclad & Regent Card Reworks

10 min read · Conflagration AOE rework, Drum of Battle exhaust engine, Parry Power redesign, Ascension curve overhaul.
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Build Guides

⚔️ S-Tier Build

Ironclad Strength Build: One-Shot Bosses with Demon Form + Limit Break

8 min read · Stack massive Strength and multiply it for 200+ damage hits.
→ 🛡️ S-Tier Build

Ironclad Corruption Exhaust Build: The Immortal Block Engine

10 min read · Feel No Pain + Dark Embrace + Corruption Trinity. The strongest A20 build.
→ 🃏 S+ Tier Build

Silent Sly Discard Build: The #1 Meta Monster (35.6% WR)

12 min read · The dominant meta build. Sly Strike + Tactician + Calculated Gamble engine. Highest WR in the game.
→ 🗡️ S-Tier Build

Silent Poison Build: Stack 999 Poison with Catalyst + Burst

8 min read · Apply and multiply Poison exponentially while blocking everything.
→ 🔪 S-Tier Build

Silent Shiv & Discard Build: Infinite Card Cycle Guide

10 min read · Accuracy + Wrist Blade + Calculated Gamble engine. Cycle your deck every turn.
→ 💀 Master Guide

Necrobinder Master Guide: Summon & Doom Builds, A20 Strategy (32.1% WR)

12 min read · Complete all-in-one guide. Both archetypes, card tier list, board management, co-op synergies.
→ 💀 S-Tier Build

Necrobinder Summon Build: Flood the Spire with Skeleton Army

8 min read · Summon minions, buff your army, and overwhelm every encounter.
→ ☠️ S-Tier Build

Necrobinder Doom Build: Skip HP Scaling with One-Turn Execute Combos

10 min read · The #1 A20 clearing strategy. Death Sentence + Grim Toll execute combos.
→ ⚡ S-Tier Build

Defect Focus & Orb Build: Become Immortal with Frost Wall

8 min read · Stack Focus, fill Orb slots with Frost, and passively block all damage.
→ 👑 S-Tier Build

Regent Sly & Star Build: Command the Battlefield

8 min read · Generate Sly, build Stars, and unleash devastating Starfall finishers.
→ ⚡ Master Guide

Defect Complete Guide: Orbs, Focus & A10 Strategy (29.8% WR)

14 min read · All 4 orb types, Focus breakpoints, 3 best builds (Frost/Lightning/Dark), card tier list, relic priority.
→ 👑 Master Guide

Regent Master Guide: Stars, Forge & Sly Resource Management

16 min read · Triple resource system explained, 3 best builds (Starfall/Sly Control/Royal Guard), card tier list.
→ 💀 Build Guide

Necrobinder Sic 'Em Build: Post-v0.107.0 Swarm Engine Guide

10 min read · Sic 'Em summon count buffed 2→3. Swarm engine combo, core cards, act-by-act strategy.
→ 💰 Budget Guide

Budget Builds Guide: Win Without Ancient Cards (All 5 Characters)

12 min read · Common/Uncommon-only builds for every character. 4 budget principles & A20 viable options.
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Boss & Endgame

💔 Boss Guide

How to Beat the Corrupted Heart: Act 4 Boss Strategy Guide

13 min read · Beat of Death counterplay, phase-by-phase breakdown, per-character strategies, preparation checklist.
→ 💀 Advanced

How to Beat A10 with Every Character: Ultimate Ascension Clear Guide

17 min read · All 10 A-modifiers explained, per-character A10 builds, universal tips, boss-specific counters.
→ 💀 Endgame

A20 Endgame Guide: Ascension 15→20 Difficulty Spike & Character Builds

13 min read · A15→A20 cliff, 5 mindset rules, per-character A20 builds, boss HP scaling breakdown.
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Character Comparisons

⚔️ VS Guide

Ironclad vs Silent: Which Starter Is Best for You?

8 min read · Head-to-head comparison: playstyles, strengths, weaknesses, and who to choose for your run.
→ ⚡ VS Guide

Defect vs Necrobinder: Orb Mastery vs Summon Army

8 min read · Which automaton fits your playstyle? Passive Orb scaling vs aggressive minion swarms.
→ 👑 VS Guide

Regent vs Ironclad: Tactical Commander or Brute Force?

8 min read · Star resource management vs raw Strength scaling — which character fits your style?
→ ⚔️ VS Guide

Silent vs Necrobinder: #1 (35.6% WR) vs #2 (28.4% WR) — Head-to-Head

11 min read · Tale of the tape, boss matchup comparison (7-1 Necro), learning curve analysis.
→ 👑 VS Guide

Regent vs Silent: Scaling Minions vs Tempo Burst — Damage Showdown

10 min read · DPS charts, playstyle comparison, v0.108.0 wishlist for Regent buffs, Silent counterplay.
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Data & Tier Lists

🃏 Tool

Deck Builder — Drag & Drop Deck Planner

Build, share & theorycraft decks. Drag & drop cards, URL sharing, cost curve analysis. All 577 cards.
→ 🏆 Tool

Tier List Maker — Create & Share Custom Rankings

Drag cards/relics into S/A/B/C/D/F tiers. Pre-loaded with expert ratings. Share your tier list via URL.
→ ⚔️ Tool

Daily Challenge Generator — Random Seeded Runs

Daily and custom seed challenges. Random character, restrictions & bonus objectives. Perfect for streamers.
→ 🔍 Tool

Card Compare — Side-by-Side Comparison

Compare any two cards side by side. Cost, type, rarity, tier, effects & upgrades. Ctrl+K to search.
→ 📊 Tier List

Complete Card Database & Tier List

Filterable database · S~F rankings for all 10 categories. Updated for v0.106.1 (577 cards).
→ ⭐ Tier List

S-Tier Cards Guide: All Ancient + v0.106.0 Strategy Pages

10 Ancient cards analyzed · 10 v0.106.0 card deep-dives with draft strategies.
→ 💎 Tier List

Best Relics Tier List & Strategy Guide (2026)

16 min read · Boss relic pick order, S-Tier relics ranked, energy relic math, trap relics, per-character picks.
→ 💎 Synergy Guide

Best Relic Combos & Synergies: Beyond Individual Rankings

14 min read · Top 20 game-breaking relic combos, per-character synergy matrix, trap synergies to avoid.
→ ⭐ Tier List

Best Powers Tier List: Every Power Card Ranked S Through B

13 min read · Corruption/Footwork+/Echo Form/Devoted Legion in S-tier. Archetype anchors ranked per character.
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